The Insula: A Stimulating Island of the Brain

Inès Rachidi (1) , Lorella Minotti (2, 1) , Guillaume Martin (1) , Dominique Hoffmann (1) , Julien Bastin (2, 3) , Olivier David (4, 5, 6, 3, 2) , Philippe Kahane (3, 2, 1)

1 CHUGA - Unité d’Épilepsie et Malaises Neurologiques, Pavillon de Neurologie, Centre Hospitalier Universitaire, Grenoble, France
2 GIN - [GIN] Grenoble Institut des Neurosciences
3 UGA - Université Grenoble Alpes
4 INS - Institut de Neurosciences des Systèmes
5 AMU - Aix Marseille Université
6 INSERM - Institut National de la Santé et de la Recherche Médicale

Direct cortical stimulation (DCS) in epilepsy surgery patients has a long history of functional brain mapping and seizure triggering. Here, we review its findings when applied to the insula in order to map the insular functions, evaluate its local and distant connections, and trigger seizures. Clinical responses to insular DCS are frequent and diverse, showing a partial segregation with spatial overlap, including a posterior somatosensory, auditory, and vestibular part, a central olfactory-gustatory region, and an anterior visceral and cognitive-emotional portion. The study of cortico-cortical evoked potentials (CCEPs) has shown that the anterior (resp. posterior) insula has a higher connectivity rate with itself than with the posterior (resp. anterior) insula, and that both the anterior and posterior insula are closely connected, notably between the homologous insular subdivisions. All insular gyri show extensive and complex ipsilateral and contralateral extra-insular connections, more anteriorly for the anterior insula and more posteriorly for the posterior insula. As a rule, CCEPs propagate first and with a higher probability around the insular DCS site, then to the homologous region, and later to more distal regions with fast cortico-cortical axonal conduction delays. Seizures elicited by insular DCS have rarely been specifically studied, but their rate does not seem to differ from those of other DCS studies. They are mainly provoked from the insular seizure onset zone but can also be triggered by stimulating intra- and extra-insular early propagation zones. Overall, in line with the neuroimaging studies, insular DCS studies converge on the view that the insula is a multimodal functional hub with a fast propagation of information, whose organization helps understand where insular seizures start and how they propagate.

Mots clés: insula; epilepsy; SEEG; direct cortical stimulation; cortico-cortical-evoked potentials

Domaines: Neurobiologie

Inès Rachidi, Lorella Minotti, Guillaume Martin, Dominique Hoffmann, Julien Bastin, et al.. The Insula: A Stimulating Island of the Brain. Brain Sciences, 2021, 11 (11), pp.1533. ⟨10.3390/brainsci11111533⟩. ⟨hal-03462974⟩